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Artificial intelligence and neural network based methods require difficult to obtain training sets.
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However, these chemical methods use organic solvents and toxic reducing agents, consume high energy, and require difficult waste treatment.
But most of current deep learning methods require solving a difficult and non-convex optimization problem.
Traditional vacuum methods are too complicated and difficult because those methods require a large number of expensive equipments, when the number of process parameters increases.
However, these methods require free field conditions that are often difficult to achieve in practice.
From a classical perspective, these methods require computationally intensive numerical integration, which is difficult to implement.
Standard sequencing methods require efficient PCR amplification and this is more difficult in viral RNA samples because of common problems in synthesizing full-length cDNA.
However, many of these methods require significant data reduction or smoothing which makes them difficult to interpret [ 6].
All these methods require the constant measurement of the crack location, which might be difficult or yield imprecise results.
However, most of these methods require careful preparation and inefficient purification methods for obtaining monofunctionalized NPs, making it difficult to scale up for practical applications.
LARCs and permanent methods are safer and more reliable for women than many short-acting methods, but these clinical methods require more training than short-acting methods and thus are seen as more difficult to provide.
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