Sentence examples for methods remains challenging from inspiring English sources

High-parameter single-cell technologies can reveal novel cell populations of interest, but studying or validating these populations using lower-parameter methods remains challenging.Here we present GateFinder, an algorithm that enriches high-dimensional cell types with simple, stepwise polygon gates requiring only two markers at a time.

RNA interference (RNAi) has considerable potential as a therapeutic strategy, but the development of efficient in vivo RNA delivery methods remains challenging.

However, the application of these methods remains challenging when using low- to medium-density genetic linkage map, as was the case here and in the majority of QTL analysis in salmonids thus far.

However, nontargeted analysis performed using a single routine method remains challenging.

Implementation of a cost-effective, robust and easy-to-use tissue preparation method prior to pathogen detection remains challenging in clinical applications, and is still problematic in nucleic acid testing [ 16].

The choice of the number of clusters (k) remains challenging for clustering methods.

Group-specific determination of biomass concentrations remains challenging with this method.

However, defining a meaningful method to create broader-scale clusters remains challenging and continues to be an open area of study.

However, estimating the dose distribution in a fast and accurate manner remains challenging, despite advances in Monte Carlo methods.

Though a few computational methods have emerged, accurate high resolution HLA typing remains challenging.

However, despite the promise of DNA-based monitoring methods, the adoption of these tools in decision-making frameworks remains challenging.