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This variability is due to the different methods performed and partly to the countries and to the time period in which studies were conducted.
In addition, data on objectively confirmed thromboembolic events including age at onset, triggering factors, imaging methods performed, and use of antithrombotic/antiplatelet therapy and its duration were documented.
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JSH contributed to the conception of study and statistical methods, performed analysis and interpretation of data, and drafted the manuscript.
IT conceived of the study, designed methods, performed surveys and experiment and drafted the manuscript.
For single-copy loci, both methods performed equally and homozygotes and heterozygotes were easily identifiable.
AZ was involved in the development of methods, performed data and sample collection, data analysis and wrote the paper.
JSH contributed to the design of study and methods, performed statistical analysis and interpretation of data, and wrote the manuscript.
Both methods performed similarly and yielded ROC curves greater than 0.80 (see Additional file 3: Figure S2).
RD provided expertise in establishing von Frey methods, performed measurements and calculated data.
In other scenarios, these two methods performed similarly, and no one consistently won the other.
When the signal is high (θ=0.35, 0.5), all methods performed similarly and have roughly the same characteristics.
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