The prior knowledge requirements of these methods often limit their realistic applicability.
The cost and complexity of those methods often limit the number of samples that can be analyzed, and therefore the scope of the studies performed.
We did not limit the maximum number of parent nodes in simulated networks, even though sampling methods often limit the number of possible parents, for reasons of computational efficiency.
Until recently, flax improvement relied mostly on conventional breeding methods often limited to an adapted but narrow germplasm base.
This method often limits its search on a set of prior candidate transcription factors, whereas our method (MULTICOM-GNET) can consider all differentially expressed TFs shown in data or even all the known TFs of a species without the need of such prior knowledge.
However, the use of conventional quantitative research methods alone often limit detailed understanding of the phenomena under study, ignore the context of the problem or intervention, minimize the impact of the changing nature of the study subject and/or its context, and exclude outliers in preference to generating implications from the mean [ 31].
Direct detection methods are often limited in patients with light or early infections, whereas serological tests and PCR methods fail to differentiate between an inactive and persistent infection and between schistosomal species.
In some cases, deterministic methods that guarantee the identification of the optimal models can be applied, but these methods are often limited by the exponential growth of the search space.
While randomisation methods are often limited in their ability to handle missing data, the scope of data collection required by our method suggests that handling missing data and understanding how it impacts the allocations are important practical considerations.
Although quite useful, existing corpora [15, 16, 28, 29] that can be used for training those methods are often limiting in developing automatic annotation systems, because they are small in size and have incomplete annotation.
However, these methods are often limited to specific study types or modelling techniques.
