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Corresponding advances in companion biomarker development, novel methods of serial tumor assessments, and innovative trial designs act synergistically to further precision medicine.
Using the methods of serial block sections of the entire endometrium of the uterus surgically removed for smaller endometrial carcinomas, we found 131 "small endometrial carcinomas".
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We develop the method of serial ANNs and show that the learned context does improve detection over traditional ANNs.
Whole-mount (WM) technique is a method of serial pathologic sectioning designed to maximize cross-sectional visualization, and enhance evaluation of margin status.
By applying the recently developed method of serial femtosecond crystallography at an X-ray free-electron laser, we successfully determined the room-temperature crystal structure of the human AT1R in complex with its selective antagonist ZD7155 at 2.9-Å resolution.
This method of serial passaging might approximate an in vivo situation in which spheroids must undergo at least partial spontaneous dissociation to implant on serosal surfaces.
This method of serial EBC pH testing allows for earlier non-invasive diagnosis of acid reflux as a cause of a patient's cough.
Since computed tomography could not be used for digitization because of insufficient density contrast, the classic method of serial grinding was applied.
In addition, 3D models created by the alternative method of serial sectioning are highly time consuming to generate and physical distortion of the sample can often occur during sectioning.
Since our method of serial spheroid passaging alternated between spheroid and monolayer culture, we were able to test the drug sensitivity of the intervening monolayer for each spheroid generation.
Finally, it should be noted that the frequently employed method of serial dilution, that is, multiple sequential dilution steps by the same factor, makes it hard to obtain as good coverage of a concentration range as in Figure 3C, which in turn often precludes acquisition of data good enough for quantitative analysis in structure activity relationships.
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