Our aim is to identify prognostic factors in parotid gland carcinoma and develop a method to define the probability of recurrence.
For given values of n and l, this method requires the computation by means of recurrence relations of two auxiliary polynomials, P ( x ) and H ( x ), of degrees 2 l − 2 and 2 l − 4, respectively (see [18]).
The parameters for these sensitivity analyses were specified based on (i) estimates from validation studies in external populations using similar methods for ascertainment of recurrence, (ii) knowledge of recurrence assessment practices by NCRI tumour registration officers and (iii) numerical constraints of the data (Jurek et al, 2009).
The primary method of detection was very different depending on the site of recurrence.
By adopting the method of recurrences, two explicit expressions have been established for sums of products of the degenerate Euler polynomials and the degenerate Bernoulli polynomials.
To define risk factors of recurrence.
6 11–13 The trial development group considered the evidence available at the time for methods of detecting recurrence early and a founding principle of the CEA Second-Look Trial was that early detection of recurrent tumour would only be justifiable if further treatment offered the prospect of benefit to the individual patient (figure 1; Slack et al, 1982, unpublished work).
In our experience the far from brilliant results obtained led us to change our follow-up in 2006 and make it less intensive, tailoring it to the stage of the disease, the reliability of the diagnostic methods, times of recurrences and no less important, the age of patients.
Subcutaneous injection of the anti-IgE antibody omalizumab is being studied as a method of preventing recurrence, but it is not yet recommended.
Systematic reviews [ 10, 15, 16] of studies which described incidence and method of detection of recurrence and survival are presented in Additional file 1: Table 2.
