Your English writing platform
Free sign upSuggestions(5)
Exact(2)
Three complementary, but different methods of pathway consolidation are explored.
We developed a web-based application, the Pathway Distiller (http://cbbiweb.uthscsa.edu/PathwayDistiller), which provides access to our integrated pathway database base, pathway enrichment and three methods of pathway consolidation.
Similar(58)
Hwang [ 32] has compared five methods of pathway-aggregation for gene expression data and report the best two.
This study evaluated and compared the six methods of pathway-level aggregation of gene expression data--five existing methods (Mean all, Mean CORGs, ASSESS, PCA, and PLS) and a simple variant of an existing method (Mean top 50%).
One method of pathway reconstruction uses Bayesian networks (BNs) to learn and model relationships between variables (e.g., genes).
Our new method of Pathway Co-expression Network is also introduced here.
To overcome these problems we took advantage of a much more robust method of pathway activation analysis [ 28].
Another natural method of pathway consolidation finds some overlap between the gene members of pathways pairs, including exact gene set matches.
Our method of pathway activation analysis instantly revealed substantial changes in several major pathways in AMD which were previously invisible at the gene expression level.
Further, Gαs adenylate cyclase PKA pathway activation can drive meiotic maturation at high rates in the absence of sperm (Govindan et al. 2006, 2009), approaching ∼50% of the maximal hermaphrodite rate, depending on the specific method of pathway activation.
The top two panels (labeled as 1 and 2) describe the two steps comprised of the pathway reconstruction part, the comparative-based method of pathway reconstruction and the validation protocol; the bottom panel illustrates the pathway visualization and data integration consisting in the second part.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com