In contrast, the Bucher method necessitates a two-step analysis in which we would first need to meta-analyse the results from the two trials of bevacizumab plus IFN vs IFN and then perform the indirect comparison of this pooled result with the result of the trial of sunitinib vs IFN.
High throughput methods necessitate publicly accessible and easily queried databases for efficiently and logically storing, displaying, and analyzing the large volume of data.
Previous methods necessitate the use of strong bases, sensitive organometallic complexes or redox reagents resulting in extensive functional group protections of complex molecules.
The study would probably be impossible to repeat, because the low failure rate with modern methods would necessitate an impossibly high number of patients to achieve a reasonable statistical power.
Shortcomings in previous native purification methods necessitated the development of a simplified and generalizable nondenaturing purification methodology.
47 Several new studies have emerged since these reviews were completed, however, and the existing reviews have used limited meta-analytical methods, necessitating our review.
This method necessitates solving a series of simultaneous equations using, for example, Cramer's rule to obtain the component intensities from the measured ones.
Since Cas9 nuclease can be injected in multiple forms, as either plasmid, mRNA, or protein, it may necessitate a particular delivery method.
The method only necessitates an estimate of the range of the uncertain variables that encapsulates the true range of the input variables with overwhelming probability.
The major conclusion of this work is that for stationary heat conduction through extended surfaces, the DTM solution can be obtained in a closed series solution which does not necessitate an iterative method such as the Newton Raphson methods for the determination of the initial value of temperature transform function.
