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Different tree reconstruction methods may furthermore produce conflicting results, giving rise to controversial conclusions [ 12, 27, 31, 32].
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Furthermore, different methods may be more effective at assessing the different levels of Miller's framework of clinical assessment [23].
Furthermore, both methods may produce false predictions due to experimental deficiencies: for IHC-based classification, false negatives may arise from experimental or subjective errors detailed above.
Furthermore, other methods may not accurately measure KD if the approach to complex equilibrium is slow and equilibrium is not reached in the timeframe of the assay.
Furthermore, serological screening methods may prove useful for identifying clinically relevant T cell antigens for immunotherapy.
Wrede [ 46] argues that case-based methods may help to capture complexity and, furthermore, highlights the benefits of interdisciplinary scholarship and methodological reflexivity.
Furthermore, postprocessing and modeling methods may affect the results and may complicate comparison across studies [39].
Furthermore, some of the methods may be used directly on the clinical samples, further reducing time and cost.
Furthermore, these biological-information based methods may improve our ability in detecting compensatory mutations.
Furthermore, in some cases GTP methods may be statistically inconsistent, even when the gene tree topologies are correct [ 20].
Unfortunately, the systems calculated by such methods may be much bigger than the initial ones, and furthermore they may be not strictly equivalent to them.
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