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While high sensitivity and specificity of these methods is well established [ 19– 27], the use of NGS provides important advantages with clarifying activating mutation rate in tumor sample as well as greater detection of rare mutations outside of target areas [ 28– 31].
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These methods are well established in the engineering community using commercial finite element packages [1, 2].
Both fabrication methods are well established and enable the fast and reliable mass production of microtubes.
Semi-quantification methods are well established in the clinic for assisted reporting of (I123) Ioflupane images.
High throughput experimentation methods are well established in many companies and in research groups in academia.
However, although the methods are well established, the mechanisms involved in the bone uptake of radiotracers still remain speculative.
When such a map is the only available sampling frame, methods are well established for drawing a simple random sample of fixed area plots.
Using α-spending functions to control the overall type I error rate, group sequential methods are well established and have been dominating phase III studies.
Whereas the first two methods are well established in the field of cheminformatics, the latter is a relatively new machine learning technique, which has been successfully applied in recent research projects [17, 18].
Although the visualisation requirements – the expected 'look and feel' – for the majority of spectra from different spectroscopic methods are well established, a dominant lack of a reusable customisable spectra viewer for the life sciences is noticeable.
Whilst the dissolution testing methods are well established and standardized for oral dosage forms, i.e. tablets and capsules, there are no pharmacopoeia methods or regulatory requirements for testing the dissolution of orally inhaled powders.
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CEO of Professional Science Editing for Scientists @ prosciediting.com