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Although the fluorine and trifluoromethyl moieties are often found on the aromatic rings of many pharmaceutical and agrochemicals rather than in aliphatic regions, this may be a result of the lack of efficient methods for the asymmetric introduction of C F and C CF3 bonds into molecules; it could be the case that lack of chemical methods is restricting useful exploration of such molecules.
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However, the application of magneto-based methods is restricted due to lack of reproducibility and renewal of the sensor surface.
The use of internal cost allocation methods is restricted to accurate ones that also take the service exchange between indirect cost-centers into account, such as the iterative method of assessment [20, 21].
The performance of such methods is restricted by the accuracy of drusen detection.
Usually, the limit of detection of these methods is restricted by the sensitivity of the optical system.
On the other hand, the abundantly available FFPE specimens are easy to handle and economic to store, but their applicability for modern analysis methods is restricted [ 7- 12].
Formalin-fixed paraffin-embedded specimens (FFPE) are easy to handle and economic to store, but their applicability for molecular methods is restricted.
However, the application of these methods is restricted by the availability of the orthogonal scans, which are not typically acquired clinically.
Currently, these methods are restricted to highly developed laboratories.
Most Bayesian variable selection methods are restricted to mixture priors having separate components for characterizing the signal and the noise.
Most of the existing metallization optimization methods are restricted to the conventional H-pattern, which limits the achievable improvements.
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