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Response assessment by conventional radiographic methods is problematical because treatment induces fibrosis and makes tumour measurements difficult.
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The investigation of eccDNA phenomenon is problematical due to high heterogeneity of these molecules and lack of adequate methods for its purification from linear DNA.
Bombing in the ruggedly mountainous countryside is problematical.
Conversely, the vaccine induces a certain number of adverse reactions, and the duration of the immunity it produces is problematical.
Everyone likes democracy, but democracy is problematical when it comes to the Senate in general and the filibuster in particular.
"The entire evacuation process is problematical," said Ruth Ann Dorrill, one of the analysts who worked on the report.
I concede that trying to rig the market against Murdoch in order to support those weaker media outfits is problematical.
But air has to be rendered through indirection, and earth is problematical because it has meanings of different depths.
Securities law geeks will have read the last paragraph and note that this maneuver is problematical under the securities laws.
First, a resurgence in hiring is problematical.
Especially if the loss of bone is extensive, the choice of the correct "spacer" is problematical.
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