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However, none of those methods is perfect and generally accepted for BRCAness determination, and in not all studies data were compared with confirmed BRCA1 mutation carriers.
Critical to their development is the availability of a corpus of curated training data, and since none of these methods is perfect, their application in the field is benefited by having the ability to manually curate the results they produce.
A variety of methods are used to detect positive selection, both past (McDonald and Kreitman 1991; Yang and Bielawski 2000; Smith and Eyre-Walker 2002; Bazykin et al. 2004; Eyre-Walker 2006; Huelsenbeck et al. 2006) and ongoing (Nielsen et al. 2007; Novembre and Di Rienzo 2009; Grossman et al. 2010), but neither of these methods is perfect.
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Neither method is perfect, however.
But no method is perfect.
"There has been so much attention to the way we count votes in the United States," Mr. Hayes said, "but we know no battling method is perfect".
No method is perfect, and any cutting can make it difficult, if not impossible, to reconstruct circuits that connect cells in disparate areas of the brain and somehow create a thinking, feeling mind.
Community detection from benchmark networks by the proposed method is perfect or highly accurate.
The 'SPOCs & survey'-method is perfect to conduct the necessary comparative analysis.
They conclude that the estimates differ substantially across identification strategies and that no method is perfect.
The one-step synthesis with hydrothermal method is perfect for the synthesis process for the narrow size distribution of nanoparticles.TGA shows that the loading content of the Ni-NiO nanoparticles is about 34.84 wt% on the PDDA-G surfaces.
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CEO of Professional Science Editing for Scientists @ prosciediting.com