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Unfortunately, the robustness of these methods is hampered by batch-to-batch variability of isolated NSC.
13 14 As a result, comparing the validity of preference elicitation methods is hampered as most studies also differ on several other aspects.
Moreover, a comparative analysis of the advantages and shortcomings of different methods is hampered by the lack of direct experimental verification of predicted TFBSs.
Yet, the development and application of orthology inference methods is hampered by the lack of consensus on source proteomes, file formats and benchmarks.
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However, most of these methods are hampered by low sensitivity to mixed infections.
To demonstrate the principle we apply the method to the beam at the end of a Compact Linear Collider decelerator, where conventional diagnostic methods are hampered by the large energy spread of the drive beam after up to 90% of its kinetic energy is converted into microwave power.
One reason for this gap in knowledge is that traditional CD4+ T cell antigen screening and epitope mapping methods are hampered by the large genome size of bacteria including C. burnetii.
Whilst genome-wide methods are hampered by the need to harmonise phenotypes across contributing studies, and the requirement to achieve genome-wide significance, these have typically generated more reproducible findings than candidate gene methods (Flint and Munafo, 2013).
Depth of coverage methods do not require breakpoint capture or have specific size restrictions, yet such methods are hampered by low signal to noise ratio due to sparse sampling (a product of low overall coverage) and sampling bias based on sequence GC-content, bait coverage, and other factors affecting capture efficiency.
The theoretical method is hampered by the difficulty of evaluating the integrals.
However, delivery of the plasmid to a different B. subtilis strain by the normal transformation method is hampered by DNA size-related inefficiency.
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