From an educational heritage of fragmentation, traditional methods seem insufficient to deal with complex issues such as Climate Change.
A theoretical analysis and a survey (n = 37) amongst experienced developers show that current development methods are insufficient to develop such instructional software.
The PVE will of course affect not only PET values, but also PCT values, as the resolution of both methods is insufficient to accurately quantify the rCBF in the cortical grey matter.
Because conventional periodontal regeneration methods remain insufficient to obtain a complete and reliable periodontal regeneration, the concept of periodontal tissue engineering has been based on the generation of the conditions necessary to improve the healing of periodontal tissues.
Also, the sensitivity of these methods is insufficient to detect protein expression when a relatively low amount of RNA (1 µg or less) is delivered to the DCs.
The absence of apoptosis in the aposymbiotic squid confirms that the experimental addition of peptidoglycan (PGN) ('Materials and methods') is insufficient to induce AO staining.
Present analytical methods are insufficient to make genetic data accessible in a clinical context, and the clinical usefulness of these data for individual patients has not been formally assessed.
Testing for mutations in IDH1 or IDH2 can now easily and effectively be performed in a clinical setting and thereby enhance the diagnostic accuracy, especially, in cases where traditional methods are insufficient to reach a definitive diagnosis.
Proteins that are under the same evolutionary constraints are likely to demonstrate the same pattern of selection across individual codon sites even if the primary sequences have evolved to a point where the sensitivity of the homology methods is insufficient to predict orthology.
Dr. Thiago M. Venancio (nominated by Dr. Aravind Iyer), NCBI-NIH, Bethesda, Maryland, United States After reading the revised version of the manuscript and the response to my comments, I still think that several assumptions of this study are likely to be wrong and the data sampling and methods are insufficient to support the author's conclusions.
