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A combination of methods including small angle neutron scattering, cross-linking MS, and HDX MS were used to construct a model of HDLs, including full length ApoA1.
Furthermore, HPLC/MS-MS offers other advantages than those associated with traditional analytical methods, including small sample volumes and rapid assay times [ 13, 14].
Generation and refinement of checklist themes and items were undertaken on an iterative basis using a range of methods including small group work in dedicated workshops; a modified-Delphi process; and telephone interviews.
Yet, there are some promising new methods, including small molecule inhibitors that block SOS-mediated nucleotide exchange and thus KRAS activation (Maurer et al, 2012; Sun et al, 2012), and KRASG12C inhibitors that allosterically shift the affinity of KRAS to favour GDP over GTP (Ostrem et al, 2013).
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With regard to the other methods, we have already described the principles of gene-exon linear regression model compared to a splicing index (SI) approach; and most methods include small modifications of the SI calculation (like PAC, MIDAS, etc) [ 23].
However, the disadvantages of using these methods include small signal changes, which preclude their routine use in fMRI studies of perception and cognition, although it is helpful to determine the exact components of BOLD signals.
Among the aforementioned methods, adsorption is considered to be one of the most appropriate techniques, but there are disadvantages to this method, including small capacity, high cost, difficulty for large-scale application, etc.
It is possible that the findings reported in these studies are due to poor epidemiological methods used, including small sample size, inability to adjust for confounding, no indication for mode of delivery, and significant variations in the measurement of the outcome variable (time to next pregnancy or birth).
We then propose and demonstrate a weighted estimator as an efficient method for including small numbers of cases from the private sector as a way to recover valid estimates of resistance in the population under study.
To increase revenues this year, the Shinnecock Powwow committee has approved some new marketing methods, including a small television advertising campaign, a ticket package with a multiple-visit option, and a Friday start that expands the event to three days.
An eight-rotor drone, the Agras MG-1 is supposed to provide a safer alternative to current methods for spraying crops, including small planes, vehicles, and handheld sprayers that dispense chemicals from backpacks.
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