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Finally, we discuss the implications of recent population growth on personalized genomics, on purifying selection in the non-equilibrium state it entails and, as a consequence, on the genetic architecture underlying complex disease and the performance of mapping methods in discovering rare variants that contribute to complex disease risk.
The strategy for gene prioritization showed its superiority to conventional methods in discovering significant disease-related genes with several types of resources, while making good use of potential complementarities among available genetic resources.
Consequently, our proposed strategy for gene prioritization showed its superiority to conventional methods in discovering significant disease-related genes with several types of genetic resources, while making good use of potential complementarities among available resources.
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The significance of this method in discovering new BMGs is discussed.
Thus, this report may provide a new method in discovering novel and selective SHP2 allosteric inhibitors.
The effectiveness of the proposed method in discovering fault characteristics and detecting faults of rolling element bearings is supported using an experimental test.
Besides, a local-based method is better than global-based method in discovering yeast essential proteins.
This points to the strength of our method in discovering complex interaction scenarios where multiple regulators may jointly regulate target genes with varying time-delays.
We adopt three large-scale leave-one-out cross-validation experiments to assess the capability of the proposed method in discovering disease genes.
It can be clearly seen from the figure that the curve (blue line) increases rapidly towards the top-left corner of the plot, indicating the effectiveness of our method in discovering disease-associated genes in this simulation study.
To eliminate such a confounding factor, we perform ab initio predictions to examine the capability of our method in discovering genes that are associated with a disease whose genetic basis is completely unknown.
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