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Using the kernel-based clustering methods, however, requires the prior determination of the kernel function and its defining parameters.
The practical application of these methods, however, requires the accurate evaluation of boundary integrals with singular, weakly singular or nearly singular kernels.
The implementation of adaptive clinical trial methods, however, requires greater planning and simulation compared with a more traditional design, along with more advanced administrative infrastructure for trial execution.
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More information and more refined methods however, require more resources.
These methods, however, require f to be twice differentiable among other conditions.
Existing BSS modal identification methods, however, require the number of sensors at least equal to that of sources (active modes).
Current dissolving microneedle fabrication methods, however, require harsh conditions for biological drugs and also have problems standardizing the drug dose.
Isotopomer abundances simulated using the EMU framework are identical to those obtained using the isotopomer and cumomer methods, however, require significantly less computation time.
Global stochastic search methods, however, require many iterations to be performed in order to achieve a satisfactory solution, and each iteration may involve running computationally expensive simulations.
Most of the methods, however, require tagged small molecules for screening to separate the drug and protein complex.
These methods, however, require intact cells and must therefore be performed before freezing the sample.
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