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Over the past three decades, these methods have undergone a rapid revolutionary progress, supported by sophisticated visualisation tools, analytical and simulation methodologies and techniques.
In the last 10 years, the testing methods have undergone major changes– both on the ground and in computer simulations.
Although high-resolution and high-dimensional NMR methods have undergone continual advancement [10 12], NMR still cannot independently elucidate novel chemical structures unless co-eluting compounds can be completely separated [8].
Both of these methods have undergone more than half a century of intensive research at a cost of more than $22.4 billion...and only in the USA.
It has been argued that 'Bayesian methods have undergone substantially greater development' [ 3, 5].
These methods have undergone several changes during the last decades, and international guidelines have been established.
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The RDS method has undergone several improvements (Heckathorn [2002], [2007]; [Salganik and Heckathorn 2004]) and is now especially suited to sampling, analyzing, and studying sparse and hidden populations with unclear borders and scales, and anonymous identities (Zhao and Pedersen [2007]).
As evident in these studies, methods that have undergone standardized validation are essential to accurately determine PTEN and PIK3CA status based on the consequential role these markers could play in aiding therapeutic decisions.
In recent years, diagnostic and treatment methods for NPC have undergone tremendous changes.
Optical methods in particular have undergone a variety of innovations due to the continuous and rapid advances in the hardware used in them, namely electronic and computer-processor devices.
Skin exposure sampling methods typically are nonstandardized, have undergone limited validation, and can be technically challenging.
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