Sentence examples for methods have severe from inspiring English sources

Viral methods have severe limitations in clinical application because of potential oncogenic, pathogenic, and immunogenic risks, while non-viral methods have suffered from low transfection efficiency and transient weak expression as MSCs are hard-to-transfect cells.

Some of these methods have severe limitations such as poor adhesion, microcrack formation and phase changes at high temperature, non-uniformity, and improper microstructural control, all of which make them inadequate for implant systems [14,15].

Light microscope methods have severe limitations imposed by the ultimate size resolution of the light-optical system.

Ensemble methods and VSSA methods have severe limitations that prohibit their use for identifying materials as "nano" or "not nano".

Obviously this method has severe limitations.

Choosing the Ilizarov method has severe consequences for patients.

In both cases the NMKL method had severe problems in detecting 2 of the 9 different salmonella strains used, viz.

As the β value method has severe heteroscedasticity, it is recommended to use M-values (logit-transformed β values) for differential methylation analysis [ 59].

If you have persistent acne that doesn't respond to the first method or if you have severe, cystic acne, then you should consider meeting with a dermatologist who can prescribe other medications.

Patients whose oxygenation status changes dramatically in 24 h under a standardised assessment method would not be expected to have severe generalised lung inflammation as in ARDS, and should not be classified as ARDS.

They used a variety of methods – given that many of these children have severe communication difficulties.