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However, the RBF-based methods have markedly been limited to handle isotropic problems due to the use of the isotropic Euclidean distance.
Improvements in the technologies involved in screening of drugs for target sites, including the use of high-throughput screening procedures, recombinant DNA techniques, combinatorial chemistry, and new computing methods, have markedly increased the number of compounds that can be tested for their ability to bind to the target.
Concomitantly, the parameterization and efficiency of the methods have markedly improved along with their cross-validation with other computational and experimental results.
These studies, as well as more recent reports using a variety of methods, have markedly altered our concept of differentially methylated regions (DMRs) in the mammalian genome and the progression of DNA methylation changes during development [ 19- 36].
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The implementation of gating methods has markedly improved the acquisitions, minimising any interference effects due to the physiological movement.
While methods for ANA detection have markedly evolved in recent years, newer methodologies generally require expensive instrumentation and/or central clinical laboratories.
19 20 Inspite of the widely varied methods, measures and contexts, the studies have markedly similar findings: when colour, imagery and fonts are removed from packs, standardised packs are perceived very differently from branded packs.
Zymographic methods for the 2D distribution of phosphatase activity in soils have markedly advanced our understanding of root-soil-microbiota interactions.
A majority of the others have markedly decreased their lending.
Linear and quadratic effects have markedly different frequency dependencies.
Patients with Parkinson's Disease (PD) have markedly disturbed sleep.
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