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Theory has long supported a model of polygenic evolution in which quantitative traits are underpinned by many genes of small effect, but empirical methods have lacked the power to detect causative loci when effect sizes are small or moderate.
Until recently, the specific characteristics of normal and abnormal slow wave propagation have remained uncertain, largely because previous research methods have lacked the spatial resolution required to resolve detailed propagation patterns.
While offering advantages over traditional points of departure (PODs), such as no-observed-adverse-effect-levels (NOAELs), BMD methods have lacked consistency and transparency in application, interpretation, and reporting in human health assessments of chemicals.
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However, the accurate numerical relationship between pulse moment intensity and exploration depth of this method has lacked research.
All these methods have lack of imaging brain tissue down to the cellular level, and thus in addition a histological examination of biopsied or resected tumor tissue is always being performed.
Previous computational methods to quantify and visualize kinetic differential expression data of three or more lineages to identify reciprocally regulated genes have relied on clustering approaches and regression methods which have time as a factor, but have lacked methods which explicitly model temporal behavior.
State-dependent modelling techniques are a powerful tool for exploring group decision-making processes, but analyses conducted so far have lacked methods for identifying how dependent an individual's actions are on the rest of the group.
Previous reviews on the effectiveness, complications and adherence to NIV treatment have lacked systematic methods.
Despite its demonstrated utility, the methodology has lacked a method for statistical testing until now.
The state has lacked a method of inducing drivers to shift to less-crowded hours and routes by charging fees to those drivers who impose high congestion costs by driving at peak times.
Until now, BCTC has lacked a systematic method for prioritization of fuel hazard mitigation treatments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com