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However, production of Na2O-containing bioactive glasses by sol gel methods has proved to be difficult.
Furthermore, RNA extracted by robotic methods has proved suitable for use in this assay.
Neither of the methods has proved superior to the other in selecting items to describe quality of life in specific health conditions [ 31].
Validating the weighted enrichment methods has proved to be challenging because there is no ground truth to compare the enriched pathways against.
Blue dye methods has proved to be highly unreliable with variable detection rates between 0% and 100% [ 15, 17, 60– 60].
The diagnosis of hereditary diseases by molecular biology methods has proved to be a powerful tool for the managing of affected families and, in many cases, for the treatment of affected members.
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However, none of these methods has proven to be reliable in children [8].
The combination of computational and directed evolution methods has proven a winning strategy for protein engineering.
The combination of different methods has proven to be useful for this.
However, accurate delineation of H. influenzae from other Haemophilus species using genetic methods has proven challenging.
Application of these methods has proven successful for identification of mutations on HCM-related genes.
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