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By 2003, the Drug Enforcement Administration had found that Purdue's "aggressive methods" had "very much exacerbated OxyContin's widespread abuse".
By 2003, the Drug Enforcement Administration had found that Purdue's "aggressive methods" had "very much exacerbated OxyContin's widespread abuse". Rogelio Guevara, a senior official at the D.E.A., concluded that Purdue had "deliberately minimized" the risks associated with the drug.
The two extraction methods had very similar extraction efficiencies, and gave essentially identical results (Figure 1A).
On model M1, differences between methods were small, and in general all methods had very good accuracy.
When the OR for treatment was set to 0.23, all methods had very small amounts of bias in the estimated treatment effect.
On 10 sites, all the methods had very close accuracy, with a slight advantage for ASTRAL-2 on the 50-gene condition.
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These methods have very low dispersion errors and require precise boundary conditions to avoid numerical instabilities and to control spurious wave reflections at the computational boundaries.
Therefore, these projection methods have very similar computation speed.
Moreover, those adaptive methods have very good practical performance making them also very good in practice for estimation.
The fractional Black-Scholes (B-S) equation is an important mathematical model in finance engineering, and the study of its numerical methods has very significant practical applications.
The BP-SA and SC-EM methods have very similar performance due to the similar procedures they adopt to solve l1−l2 optimization problems.
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