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BA assisted in the development of the study protocol, methods for subject recruitment, and statistical analyses.
A detailed description of the design and methods for subject recruitment, scheduled returns, epidemiologic data, medical procedures, and biological sampling has been described elsewhere [ 12].
We decided not to try to derive a pooled estimate across studies of the associations of lead dose biomarkers with cognitive function because of differences in methods for subject selection, blood and bone lead measurements, neurobehavioral outcomes, approach to regression modeling, and presentation of results across studies.
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It has contracts with schools in all 50 states including school districts in Chicago and Washington, D.C. and the entire state of Indiana and has compiled 3 terabytes of data it uses to refine teaching methods for subjects like reading and math.
We used different training methods for subjects, including practice interactions with other human participants, interacting with agents from the literature, and asking participants to design an automated agent to serve as their proxy in the task.
As an example, Table 1 provides threshold criteria used for each method for subject 5. Since the true hub classification is not known for brain networks, functional cartography was utilized as an alternate to centrality measures.
DJS created the method for subject-specific identification of time varying elastance and contributed to the development of the identification of the CVS model parameters.
The method used to calculate LDL cholesterol was based on triglyceride concentration at screening (Friedewald equation for subjects with triglycerides ≤400 mg/dl [4.5 mmol/l] and Lipid Research Clinic β-quantification method for subjects with triglycerides >400 mg/dl [4.5 mmol/l] and ≤500 mg/dl [5.7 mmol/l]).
We first train the methods for each subject on the training data and then evaluate them on the testing data for this subject.
Analytical methods for this subject have been introduced in ([Pritsker and Happ 1966]; [Pritsker and Whitehouse 1966, 1969]; Pritsker 1966; [Whitehouse 1973]).
Based on the constructed network, we calculated the topological properties of the global network (see Materials and Methods) for each subject and show the mean values of these properties for the normal control (NC) and early blind (EB) groups in Table 3.
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