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Several predictive test methods for endocrine disrupters have been evaluated by international organizations.
The European Commission is actively involved the efforts of the OECD to develop agreed test methods for endocrine disrupters.
This study was designed to investigate whether phenolic compounds have estrogenic effects in these useful screening methods for endocrine disruptors.
Clear goals are articulated for the development of screening and testing methods for endocrine disruption.
ORD has articulated clear goals for the development of screening and testing methods for endocrine disruption and is fulfilling those goals in an admirable fashion.
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In order to develop facile, fast and sensitive detection methods for endocrine-disrupting chemicals (EDCs), we described a sensitive biosensing system involving magnetic relaxation switch, based on the assembly of cross-linked superparamagnetic iron oxide (CLIO) nanoparticles induced by the antigen antibody biorecognition.
We observed ProDiGe performs 1.3% worse than Smalter's method for cardiovascular disease but 1.3 2.8% better than Xu's method and Smalter's method for endocrine diseases, showing that it cannot achieve consistently better results than other methods.
This study points to the possibility of using the AMPHITOX test as a screening method for potential endocrine disruption as well as the combined effects of chemical mixtures.
The OECD has developed, optimized, and validated numerous in vitro and in vivo methods for testing the endocrine activity of substances and related effects (mammalian and non-mammalian toxicity).
In the remainder of this article the objectives and major findings will be presented with an update of the methods for cardiovascular diseases, endocrine diseases, liver diseases, neurological diseases, ophthalmic diseases, psychiatric diseases, respiratory diseases, as well as for genetic and biomarker studies and for pharmaco-epidemiologic studies.
Internationally agreed and validated test methods for the identification of endocrine disruptors capture only a limited range of the known spectrum of endocrine disrupting effects.
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