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The general approach and criteria for validating methods for dose formulation analysis are instrument-independent.
The U.S. EPA identifies three methods for dose addition: relative potency factors (RPFs), toxic equivalency factors (TEFs), and the hazard index (HI).
Generally, to increase the AUC0 24, increasing the dose (e.g. IV 400 mg to 600 mg) or the frequency of dose (12-hourly to 8-hourly) are the more common methods for dose adaptation.
The two commercially available products, SIR-Spheres® (Sirtex Medical Limited, North Sydney, NSW, Australia) and TheraSphere® (Nordion, Ottawa, Canada), use empirical methods for dose calculation, based on body surface area and total liver weight respectively.
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Another method for dose reduction relies on decreasing the image frequency of acquisition from the PCT first-pass data [35].
Two different methods are developed, one method for channel loop functionality test and another method for dose alarm test using electronic transient pulse.
Diagnostic Reference Levels (DRLs), a well established method for dose optimization, are not yet defined for CBCT and have to be set for various clinical indications.
These promising hypothesis-generating studies require robust long-term control and toxicity data, but they do indicate that focal boosting (and focal salvage therapy) using mpMRI-guided HDR and LDR is a feasible method for dose escalation while minimizing OAR toxicities.
One emerging method for dose escalation to improve local results is stereotactic body radiation therapy (SBRT).
Here we propose the MADCE method for dose estimation, which is based on improvements over the MAC-PR method.
In addition, this determination provides a noninvasive method for dose selection to monitor the response to antioxidant treatment [ 86].
More suggestions(15)
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