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Analytically, one derives two classes of steady-states (see Methods for derivation of conditions): (I)(EGF* = 0 ∧ R* = 0) ∨ R_EGF* = 0, (II) CDE ∗ = 0 ∧ CIE ∗ =0 ∧ R_EGF ∗ = k f k r EGF ∗ ∗ R ∗, where X* denotes the steady-state concentration of the respective component.

Methods for derivation of NEDI-USA have been previously described [5].

To establish such a tool, a database of the characteristics of about 87,000 ships is acquired and various methods for derivation of empirical relations are employed.

Methods for derivation of lung epithelial cell lineages from embryonic stem cells have been established and are currently being refined; the existence of multipotent adult human lung stem cells that give rise to epithelial and vascular tissue has been reported.

When using preference-based measures for health outcomes, such as health utilities, to calculate Quality-Adjusted Life Years (QALYs), decision modelling guidelines recommend that the utility weights are incorporated into the model appropriately, and the methods for derivation of utility weights are justified [25].

Error bars represent two standard deviations from the mean (see 'Materials and methods' for derivation).

Interpretation of published data and the appropriate methods for derivation of RRs were discussed by all authors.

The methods for derivation and validation of the DAVROS risk-adjustment model have been described in detail elsewhere.

See Table  1 for abbreviated results and " Methods " for derivation details. (XLS 33 kb) Additional file 2: This file contains Figures S1 S7 as well as Tables S2 S9.

Our results highlight the importance of close monitoring of genomic integrity and the development of improved methods for derivation and culture of hPSCs.

Where appropriate, difficulties in interpreting published data or in the appropriate methods for derivation of RRs were discussed by BAF and PNL.

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