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Qualitative methods for confirmatory studies are well supported by critical realism [ 68, 75] and realist approaches are gaining credibility in relation to evidence-based policy and programme evaluation [ 73, 74, 76].
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The developed UHPLC-MS/MS method fulfils the requirements for confirmatory methods laid down in Section 2.3.3 of Commission Decision 2002/657/EC [ 36].
A measurement model was developed using the AMOS tool and Maximum Likelihood Estimation (MLE) method was chosen for confirmatory factor analysis.
The calculated detection capabilities (CCβ) of these compounds are between 0.5 and 2.5 μg kg−1 and samples spiked at 5 μg kg−1 were found to be non-compliant based upon the ion ratio criteria [ 1] in 100% of the cases (n = 21), indicating that the method is suitable for confirmatory analysis of these antiviral drugs at relevant levels.
Though advances in mass spectrometry are being made through the use of a zwitterionic hydrophilic interaction chromatography column (Diener et al. 2007), nevertheless mass spectrometry methods are more suitable for confirmatory analysis rather than screening methods due to their high expenditure and the requirement of dedicated skilled scientists for processing the data for quantitative analysis.
It was the method of confirmatory diagnosis for 1 patient (performed on a bone marrow aspirate that had no visible amastigotes).
A direct comparison of methods for prediction of confirmatory trial outcome based on early trial data can both provide guidance on which methods to select for prediction of HbA1c and inform trial design with regard to the choice between FPG and 7-to 11-point SMPG profiles and the choice of sampling schedule.
For confirmatory methods, we make comments in the Methods and Results concerning the theoretical basis for statistical performance.
If NICUs have access to POC blood gas analyzers with glucose modules (accuracy is comparable to laboratory methods), the time delay for confirmatory analysis would be reduced compared to sending the sample to the laboratory for analysis.
As a result, the plausibility of previous research findings can be evaluated in relation to new data, which makes the proposed method an interesting tool for confirmatory strategies.
Validated confirmatory methods for complex matrices, like sediment and aquatic organisms' tissues, are very limited.
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