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Monte-Carlo simulations were performed to demonstrate the effectiveness of both methods for cases where both the array and data sample sizes are small.
Our ascertainment methods for cases and controls may have been an additional source of bias.
Haemoglobin will be assessed using a portable spectrophotometer (HemoCue AB, Angelholm, Sweden) for controls or using standard hospital laboratory methods for cases.
Thus, it has to be proven in the future, whether ultra-deep NGS like 454 may provide more reliable results than the currently established methods for cases of high CNs per diploid genome.
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We also extracted data on each study's methods for case validation.
Figure 8 shows the warning areas and predicted seismic intensities in the IPF and PLUM methods for case No. 1.
Various statistical analysis methods for case-control data have been developed in the literature (e.g., Prentice and Pyke 1979; Breslow and Cain 1988; Breslow and Day 1980; Schlesselman 1982).
The methods for case ascertainment significantly impact incidence estimates.
However, the proportionality assumption was not examined because of unavailability of appropriate methods for case-cohort studies at that time.
To analyse the matched-pair interval data we will use standard methods for case-control data (Mantel-Haenszel estimator).
In this article, we focus on improving the sensitivity of machine-learning methods for case identification in epidemiological studies.
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