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True biologic differences between RNA levels and DNA gene amplification, analytic variability of two different testing methods, extent of chromosome 17 polysomy, and dilution of mRNA obtained from tumor with those from other nonneoplastic elements can all lead to discordant results 27, 28.
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However, there is growing interest in a more conservative approach and the method, extent and even the need for elective treatment is a matter of debate[ 4 ].
Data on the extent of the disease, pathomorphology of the tumor, treatment method, extent of breast and axillary lymph node surgery, complications after the surgery, disease recurrence, cause of death, length of survival, and length of breast cancer-specific survival were collected.
Materials and methods: The extent of 18F-fluorination of labeling precursor was followed via radioTLC (EtAc:hexane 1 2).
Parallel to this finding, using histopathological methods, OA extent and severity in the simvastatin-treated group decreased compared with in the untreated group.
In contrast to most conventional methods, the extent of fouling can be detected considering the flow rate and pressure drop when the heat exchanger operates in transient states.
To understand women's preferences for specific features of contraceptive methods, the extent to which features of existing methods match women's preferences and whether this match differs by racial and ethnic subgroups.
Following sacrifice and perfusion fixation for electron microscopy (see methods) the extent of the cortical lesion was mapped in all mice to ensure comparability (Figure 1B).
Using profile based search method (See Materials and Methods) the extent of similarity of bacterial homologues with different subfamilies of eukaryotic protein kinases has been analysed.
With comparison to conventional methods, the extent of the lipid headgroup hydrolysis reaction can be determined directly within the intact membrane because of the negative charge on the product lipid.
Germline testing has to date identified 42 cases with a deleterious mutation in either BRCA1 or BRCA2; a full description of the methods and extent of mutation testing can be found in Dite et al (2003).
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