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The surveillance methods evaluated here are primarily useful for detecting outbreaks caused by resistant organisms.
Of the other alignment-free methods evaluated here only CVTree showed a consistent improvement over the baseline.
Furthermore, the values of diagnostic parameters, including specificity, sensitivity, positive and negative predictive values and positive likelihood ratio, are the highest among the three methods evaluated here.
In summary, the cytokine measurement methods evaluated here were found to be reproducible for laboratories using commercial assay platforms; however, the measured values of identical samples varied across laboratories and assay platforms.
The similarity score between a gene and a pathway was calculated by the annotated GO terms of the gene and the overrepresented GO terms of the pathway using the 6 methods evaluated here.
The five methods evaluated here are: MAS 5.0 (Affymetrix Inc., 2002), RMA (Irizarry et al., 2003), GCRMA (Wu et al., 2004), FARMS (Hochreiter et al., 2006) and DFW (Chen et al., 2007).
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There is now a need for novel methods of monitoring, such as the reference range method evaluated here, which should be evaluated in ongoing studies of monitoring for validation against clinical progression events and disease outcome.
Compounds primarily affecting the contractility properties of the heart (eg. Blebbistatin) may be missed by electrophysiological methods, but can be evaluated here.
To our knowledge, the combination of these two methods was used and evaluated here for the first time and is also eligible for other DIGE studies.
Further, performing multiple iterative rounds of global and local alignment, and perhaps even local reassembly, will benefit the overall alignment sensitivity and accuracy of all methods; however, this is not evaluated here.
For the case of exponential functions, these integrals are evaluated here and specific methods for their computation are presented.
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