The rapid growth, usage specifications, application domain and method diversity of contemporary computational biology resources presents an impediment to finding, comparing and integrating such data and tools.
Also, it is strongly advised that when analyzing the data, one must be aware of any additional factors that can influence the functional analysis, including sample preparation, sequencing method, diversity of the environments, etc. Proper calibrations, normalizations and statistical tests for significance should always be performed in order to arrive at the most reliable conclusions.
Hunter Gaston Discriminatory Index (HGDI) is a widely used estimator of discriminatory power of genotyping methods and diversity of molecular markers in bacterial pathogens, including Mycobacterium tuberculosis.
By using culture-dependent and -independent methods, considerable diversities of chiA genes and predicted catalytic activities were found.
Strategic Foresight methods engage a diversity of disciplinary- and situated-perspectives and create a safe space to reveal, test and constructively contest assumptions and enable consideration of less familiar future possibilities.
Giaever et al. [ 18] and Birrell et al. [ 39] first observed the lack of correlation between fitness and expression profiling methods in a diversity of growth conditions.
Thomas, B., Macdonald, S., Hicks, M., Adams, D. & Hodgetts, R. (1999) Effects of reforestation methods on genetic diversity of lodgepole pine: an assessment using microsatellite and randomly amplified polymorphic DNA markers.
This wide range of methods and a diversity of file formats used in sequence analysis is a significant issue, with a considerable amount of time spent before anyone can even attempt to analyse the genetic basis of human disorders.
The limitations of this systematic review include the overall poor methodological quality of the included studies, with differing study designs and analytic methods, and extreme diversity of measurements among different studies.
To monitor the culture process of iPSCs with the quantified data to evaluate the culture status, we here introduce image-based visualization method of morphological diversity of iPSC colonies.
