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However, as the methods discussed below will show, there is no mathematical sense in which the various criteria are being optimized.
The methods discussed below assume that P is quadratic in λ for the eigenvalue computation, that is, the nonlinear dependency of K on the frequency is ignored.
A pipeline to wrap methods discussed below, known as the Northern Arizona SNP Pipeline (NASP), is publically available (tgennorth.github.io/NASP/).
A multiple sequence alignment (MSA) is usually necessary before any of the methods discussed below can be implemented and is therefore a critical step.
The limited success is a result of different reasons including limitations of the current protein quantitative methods (discussed below) and the lack of more active collaborations between proteomic and clinical committees [2,5].
Also beyond this paper's scope is the background science needed to analyze genetically-driven differences, although the HTE methods discussed below may be used in an exploratory manner in that area.
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We, therefore, undertook a sensitivity analysis using the Weibull parametric tail completion method (discussed below).
Quadrature of the Parabola demonstrates, first by "mechanical" means (as in Method, discussed below) and then by conventional geometric methods, that the area of any segment of a parabola is 4/3 of the area of the triangle having the same base and height as that segment.
The details of this will be addressed in the level set-based adaptive convolution (LSAC) method discussed below.
More details on alternative methods are discussed below and proposed in the Results and discussion section.
Each of these methods is discussed below, briefly.
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