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None of the three methods demonstrated good trending ability according to concordance analysis.
However, studies have shown that when used in conjunction with a standardized protocol and quality-controlled reagents, PCR-based HPV detection methods demonstrated good interlaboratory agreement 71.
Both the Berlin and Aarhus methods demonstrated good to excellent inter-observer reproducibility for status scores (ICC: FASSS, 0.96 vs. Berlin, 0.97 [ 8]; Aarhus, κ = 0.68 [ 7]) when assessed by radiologists, but there are no data available for the reliability of change scores or the smallest detectable change for these systems.
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Current methods demonstrate good results on non-enhanced T1-weighted images, but struggle when confronted with other modalities and pathologically altered tissue.
In contrast, our proposed methods demonstrate good performance for inferring the change points at which the network topology changes.
The proposed method demonstrated good linearity and high enrichment factor.
The adopted method demonstrated good linearity for clematichinenoside AR (r2>0.9994) and five impurity components (r2>0.9992).
More importantly, this method demonstrated good performance when applied to tissues from colon cancer patients, which exhibits great potential in the practical application of telomerase-based cancer diagnosis in early stages.
The optimized method demonstrated good performance in terms of specificity, LLOQ, linearity, recovery, precision and accuracy, and was successfully applied to quantify WM-5 in mouse plasma to support the pharmacokinetic study.
Several parameters were assessed in order to optimize the efficiency of the method, such as the type and flow rate of the mobile phase, the various SPE columns, chromatography as well as different sources and ionization modes for MS. The method demonstrated good linearity (R2 > 0.993) and precision with a coefficient of variance of less than 10%%.
Under the optimized experimental conditions, the DF-KIT-6 based SPE coupled with HPLC-UV method demonstrated good sensitivity (0.4 4.6 ng mL−1 detection of limits) and linearity (R2 > 0.990 for 10 2000 ng mL−1 of KEP and IBU, and 1 200 ng mL−1 of NAP).
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