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Apart from a difference in the choice of validation population, each study had different inclusion criteria, follow-up, ascertainment methods, definition of diabetes and CVD endpoints.

Following the methods definition of hypotheses 1 to 3, the evidence is obtainined for hypothesis 2 (the curves have the same growth rate) versus hypothesis 3 (the curves have different growth rates).

Our methodology for the curriculum design included identification of learning needs in each partner country, formulation of the aims, objectives and learning outcomes, development and organisation of the content of the curriculum, development of the teaching methods, definition of the educational strategy and educational environment, and delineation of an assessment strategy.

We used the STROBE [ 17] criteria as a guide to consider key aspects of study design: sampling methods, definition of study population, inclusion and exclusion criteria, assessment of exposure, assessment of outcome(s), completeness of follow-up, treatment of missing data and treatment of possible confounding variables.

Further, a recent systematic review and meta-analysis of seven controlled studies (patient N = 14,520) of the effects of NaP versus comparator on kidney function showed that there is significant clinical heterogeneity in the populations studied, study methods, definition of kidney injury, and results [ 95].

Similar(54)

Heterogeneity across studies concerned many features, including studied populations, events considered, causality assessment methods, definitions of preventability and severity.

An additional outcome of the project is to build a sustainable network of organizations, which can provide support and advice on tasks related to syndromic surveillance: management, partnership with data providers and users, statistical methods, definitions of syndromes and dissemination.

Studies of the prevalence of FOC have been made with very different methods, definitions of samples and settings with the result that estimates a notably wide range from 3%to20%0% [ 7- 10].

In the multi-objective clustering methods, the definition of the types of representation methods, encoding techniques, and number of clusters defined (fixed/variable) are presented.

See Material and Methods for definition of extreme probe.

In conclusion, a number of methods for definition of the region of interest are described in the literature.

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