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Hence, the current work contributes to the literature by providing not only a standardized dataset available to the public, but also a realistic estimate of the performance that published methods can currently achieve in preclinical drug discovery using public data.
On the other hand, only structure-based methods can currently be used for the large number of remaining allotypes, including almost all of those for HLA-DP, HLA-DQ, and non-human allotypes.
We believe that none of these methods can currently be considered a gold standard.
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Although there is no specific international standard [16], the method can currently be described as good practice.
The main class of pure shift methods that can currently compete with PSYCHE in terms of sensitivity is that of band-selective methods.
The determination of the metal or possibly of its metabolites in biological media and the cytogenetic examination of somatic cells are two methods that can currently be used to monitor exposure of populations at risk.
However, as conflicting findings appear frequently following both self-applied and professional methods, research can currently not proclaim one technique to be superior to another in the management of dentin hypersensitivity.
Currently, de novo methods can correctly predict only 70% of individual exons and all the coding exons of 20% genes in the human genome, with a large number of false-positives [ 18].
While currently available methods can identify components of RNAi datasets that interact with each other within PPI networks [ 7], no method currently exists to determine which of these screen "hits" are novel components of well defined pathways known to regulate the process under study.
Following recent advances in medical ultrasound imaging methods almost all human tissues can currently be examined.
Currently, the methods can take advantage of more precise geometrical description to achieve more accurate models reflecting real internal structure of the material.
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