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This is not very surprising given the fact that CPORT outperforms all of these methods by at least ten percent.
Compared with the CMA-based methods in HelixCorr, direct or two-level TM hit outperforms the single methods by at least 2-folds, which is ∼14% and 21% in contact pair prediction, respectively.
On a set of 82 sequence variants, vipR achieved an average sensitivity of 0.80 at an average specificity of 0.92, thus outperforming the reference methods by at least 0.17 in specificity at comparable sensitivity.
In some situations, the effect is dramatic; for instance, in the case of a small reference database and 400-bp mean read length, increasing the number of rpoB reads from 50 to 200 increased the topological error of all three methods by at least 40%.
Using only one lane (~90,000 reads), we found that approximately 20% of such genes were covered (defined by splice site identity; see Materials and Methods) by at least one read, and this percentage increased gradually to 38% when we used more and finally all 32 lanes.
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It is believed that antioxidant activities of medicinal plants must be evaluated by more than one method (by at least two methods) in order to take into account different modes of action of a given antioxidant [ 21].
A feasible first step in patient safety education, favored by our students, and validated as an effective method by at least two schools, is the use of standardized patients to learn the art of error disclosure [ 20, 21].
Data were entered into OpenClinica version beta 3.1.2 clinical trial software (Isovera Inc, Boston, MA, USA) for clinical data management, using the double-entry method by at least two independent researchers for completeness.
As shown in Table 7, the developed CRF model still achieves satisfying F-scores on both datasets and outperforms the F-score of the best dictionary-based method by at least 0.0615.
The experimental validation of novel CNV calls was carried out using SYBR-Green-based (Stratagene) real-time quantitative polymerase chain reaction (qPCR) method by at least two independent PCR assays.
The quantitative linearity, sensitivity, and resolution of this analyzer surpass those of image analyzers used with TV cameras by two orders of magnitude, and the sensitivity, reproducibility, and facility of this method are greater than those of the high-performance liquid chromatography method by at least three orders of magnitude (Sutoo et al. 1998, 2002).
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