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Homogenous fluorescence methods are providing an important tool for HTS technologies.
In the current development stage, the introduced methods are providing useful information and allow deep insight to the measured data.
Single-molecule methods are providing new and powerful tools for dissecting the mechanisms of this complex process by virtue of their ability to provide views of protein structure and dynamics without associated ensemble averaging.
New automated analytical platforms based on FISH technologies and tissue microarray methods are providing a rapid means to determine the impact of consistent genomic aberrations in clinical trials, and in studies designed to investigate differential chemotherapeutic response.
Insights from these multiscale computational modeling and experimental methods are providing us with a means to predict, engineer and manufacture bone tissue in the laboratory and in the human body.
Here we discuss a few examples of how single-molecule methods are providing new insight into the biophysics and complexity of these proteins by avoiding ensemble averaging, thereby providing direct information about the complex distributions and dynamics of this important class of proteins.
Similar(51)
Two identification methods are provided.
Hints regarding appropriate methods are provided.
Detailed methods are provided in the following remarks.
Additional methods are provided in Methods S1.
Detailed methods are provided in File S1.
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