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Some methods applied a weighting system to criteria (DEFRA) (9, 10, 30 ) because it is not appropriate to consider all criteria on the same scale.
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The research was conducted using quantitative research methods applying a questionnaire technique of personal design.
With the exception of Quantile normalization, all used methods apply a multiplicative factor to the expression levels of each sample, equivalent to the addition of a number in the usual log2-scale for gene expression levels.
Filter methods apply a statistical measure to assign a score to each feature.
In order to extract target measurements, traditional tracking methods apply a detection threshold at every scan.
These methods apply a 'hard' clustering of SNPs (genes) so that a SNP (gene) cannot belong to multiple groups.
An example of methods applying a similar idea can be found in multi-objective iterated greedy search (see e.g. [22,37]).
More stringent normalization methods apply a multiplicative and an additive factor, i.e. they modify location and spread of the original distribution (e.g. scale normalization).
Several early computational methods apply a range of statistical and phylogenetic techniques to the problem (Casari et al., 1995; Lichtarge et al., 1996; Livingstone and Barton, 1993).
Additionally, t-test and SAM were used as alternative DEGs selection methods applying a Benjamini Hochberg multiple test correction to the resulting p-values.
If a stain is giving you trouble with normal methods, apply a modest amount of vinegar with a soft rag or towel.
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