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Data, methods and publications must be open (Masum et al., 2013) and reproducible (Sandve et al., 2013).
IPD-MA are clearly the gold standard of meta-analytic methods and publications featuring results from IPD-MA are growing steadily in recent years.
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(Unfortunately, that plan has hit a snag: 23andme has been told to cease operating by the US Food and Drug Administration because it has failed to respond to inquiries about its testing methods and publication of results).
The following information was collected in a predefined data collection form: first author's name, publication year, country, sample type, total number of cases and controls, quantitative methods, and publication language.
A benchmark paper will be selected based on its completeness (eg, breadth of topic), rigour (eg, reviewing methods) and publication year; most recent/latest review usually reflects the inclusion of a greater number of relevant studies.
When including study characteristics (method and publication status) in specification 2, the results remain very similar.
Next, users can review the associated metadata (e.g. data source, antibody, platform, analysis method, and publication) and use this information to refine the selection, after which it is then possible to browse the selected tracks in the browser.
Informed consent was obtained from all participants in accordance with the Declaration of Helsinki [ 22]after they were informed of the purpose, method and publication of the study, that participation was voluntary, and that they could withdraw at any time.
Informed consent was obtained from students and clinical teachers in accordance with the Declaration of Helsinki [ 24] after they were informed of the purpose, method and publication of the study, that participation was voluntary, and that they could withdraw from the study at any time.
Interactions are annotated with supporting information, such as interaction type, experimental detection methods and supporting publications.
We excluded (1) publications of single studies, (2) legal reviews, commentaries, or narrative literature reviews with no systematic review or meta-analytic methods, and (3) publications not written in English from our summary.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com