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Since exacerbation outcome in the RCT is measured with two methods, analyses will be based on the event-based approach, on the symptom-based approach and on a combination of both.
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Cluster specific methods and multilevel analyses will be used, because the PHCC rather than the patients were randomised.
Complementary methods and stratified analyses will be deployed, if necessary, to study the distribution of the causative agents of pneumonia according the underlying medical condition such as HIV for example.
Regardless of the method chosen, sensitivity analyses will be performed to compare the results to complete case analyses [ 46].
Additional statistical methods used for the longitudinal analyses will be detailed in the respective publications.
Sensitivity analyses will compare methods relying solely on EMR-derived data versus analyses supplementing EMR data with conventionally collected patient and clinician data.
In many laboratories the methods available for routine clinical analyses will only identify Salmonella, Campylobacter, Shigella and Yersinia, and Clostridium difficile or certain variants of EHEC are investigated on separate request.
Follow-up will be estimated using the reverse Kaplan Meier method Univariate and multivariate Cox analyses will be done to calculate the Hazard Ratio with 95% CI.
The robustness of ecological landscape analyses will increase as methods are devised that remove the subjectivity with which observational scales are defined and selected.
Improving the quality of economic analyses will require better methods for estimating payments.
Secondary analyses will use similar methods to compare the outcomes between groups for the additional outcomes (cognition, language etc).
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