The method described in this paper, besides using traditional image segmentation methods, also incorporates anatomical information, making the algorithm robust enough to deal with pathological cases.
Statistical modeling takes into account age-related penetrance and phenocopy rates, with advanced methods also incorporating in-silico predictions and co-occurrence with a known pathogenic variant into a single quantitative measure of pathogenicity.
The particle method also incorporates a variance-reduction technique which can significantly reduce statistical error in first and second moments of selected mean flow quantities.
This method also incorporates a modification of the reversible averaging method of [J. Comput. Phys. 171 (2001) 95] based on an interpolation of the forces acting on the fast variables which is potentially much more efficient than the original method.
The TD HF method (also called the random phase approximation, RPA) includes some double excitations, giving a slightly correlated description of both ground and excited states, The CIS(D) method also incorporates some double substitution corrections to the CIS energies, in a size-consistent way.
The method also incorporates some probabilistic elements to enable wider record matching.
Our method also incorporates the freedom to encode complex design criteria, which is not possible with the APM.
In contrast to a pseudo-testcross approach, which utilizes markers that are heterozygous in one parent but homozygous in the other, the new method can also incorporate markers that are heterozygous in both parents.
In addition to these manually assigned terms, GOA generates high-quality GO assignments using a number of electronic methods and also incorporates annotations from a range of other GO Consortium member databases.
With regard to the relatively high amount of missing CCQ data in our study, future attempts should also incorporate methods to enhance compliance, such as reminders and possibilities to provide feedback or support.
