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We extracted information on study design, quality, participants, sample collection methods, adjustments for potential confounders and correlations between PBDE concentrations in internal and external matrices.
The overall associations observed, however, were similar across other subgroups such as latitude of study location, sex, study quality, levels of multivariate adjustment, assay methods, adjustments for seasonality or socioeconomic status, and geographical location (figures 3, 4, and 5 and eFigure 4).
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However in two studies using comprehensively controlled multivariate methods, adjustment for stage at diagnosis did nothing to change socioeconomic differentials[ 6, 15].
To modify the manuscript, we have added the following sentences in Materials and methods, "Adjustment of Mutation Frequency": "To consider tumor content we performed CD19/CD5 FACS analysis to quantify the fraction of tumor cells".
We then applied methods (adjustment, restriction, and inverse probability of attrition weighting) to mitigate these biases in analyses using Cox proportional hazards models to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).
Using the MAIC method, adjustments for observable cross-trial differences at baseline were made using IPD.
By using this method, adjustments were made for the opportunity cost of the production the individuals could have contributed with if they had been at work [ 19, 21, 26].
The observed difference of 11 min in our sample is not significant, when applying the survey/panel method adjustment for multilevel modelling or the full-adjusted model (see figure 2).
Ultimately it is not possible to remove the effects of bias through adjustment and methods of adjustment based on logistic regression may increase bias [ 27].
As with individual data, the methods of adjustments are reported (Dec ID and Inc ID).
For both methods CI adjustments were made using Sidak correction.
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