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In the 1860s and '70s it was a rallying point for the Molly Maguires, a secret miners' society that struggled to improve mining conditions, often with violent methods; a trial in Pottsville (1877) resulted in six hangings and numerous prison sentences of suspected members of the society.
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Furthermore, a research article offers only a limited space to explain and reflect on the methods of a trial.
Explicit descriptions of methods before a trial starts help to identify and deter unacknowledged, potentially biased changes made after reviewing the study results.
This paper describes the design and methods of a trial of the READY psychosocial resilience training program, which will provide data on each of these issues.
In this paper we describe the design and methods of a trial aiming to rationalize antibiotic prescribing by decreasing this uncertainty and parental anxiety.
The aim of this paper is to describe the design and methods of a trial assessing the cost-effectiveness of ultrasound imaging as a diagnostic triage tool to improve management of primary care patients with non-chronic shoulder pain.
Whilst it is important to agree upon strategies for implementing and assessing fidelity to treatment delivery during the design phase, researchers should still be prepared to adapt their planned methods during a trial in line with evolving issues.
This method, inspired by the classic SQP method, calculates a trial step by a quadratic semidefinite programming subproblem at each iteration.
Methods: A full trial protocol has been published2.
The use of such blinding method in a trial involving the younger subset of the paediatric population may therefore be problematic.
As described in the methods, an ambiguous trial would occur when the residuals of the linear and logarithmic models had a difference less than ± 0.4 units.
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