For the identification of significantly mutated genes, we applied a novel analytical methodology, mutation significance with covariates (MutSigCV) [ 10], to avoid the false-positive findings detected by the standard significance analysis method (MutSig1.0) [ 55].
Francis noted that "the methodology and significance of these statistics are subject to academic controversy" but also that "there is strong evidence to suggest that these figures mandated a serious investigation of the standards of care being delivered".
The reasons for this are not clear but are likely due to differences in inherent methodologies and significance thresholds (the high stringency option was used in the DAVID analysis).
It is of great methodology and practical significance for us to realize this point of view.
The methodology of hydric significance represents an innovative approach towards assessment of ecosystem function of water retention on regional level.
After each article or abstract, respondents were asked to rate the quality of the study, the appropriateness of the methodology employed, the significance of the findings, and its likely effects on their practice.
Despite these limitations, the ADAS-CogIRT methodology holds great significance for clinical trials of Alzheimer's treatments.
The relative emphasis given to studies was based on our appraisal of the rigor of their methodology and the significance of their findings.
Our integrative method, iMCMC, will be a helpful complementary tool in the identification of cancer pathways and as a general methodology with practical significance, it has a potential to be employed in cancer research.
The treatment effects in the simulated trials and the huperzine A trial were investigated using the ADAS-CogIRT scoring methodology at a significance level of α = 0.05/3 since treatments are evaluated in the three domains of memory, language, and praxis simultaneously.
