Since H-HRMAS NMR analysis do not compromise the biochemical and structural integrity of cells and tissues, it is considered that the lipid changes detected by a such methodology originate from the biochemically active pools of the sample (Weybright et al, 1998).
We carefully combined elements of proven methodologies originating from more junior educational levels, like flipped classrooms, with those from postgraduate teaching, like case-study methodology.
Our methodology originates from the adaptive clinical trial literature, and we will draw some comparisons between the two fields.
The methodology originated in the early 1950's, when an Air Force-sponsored Rand project, titled "Project Delphi" sought to reach consensus, through a series of questionnaires and controlled feedback, among military experts on possible U.S. industrial targets for attacks from Russia [ 26].
In follow-up measurements, we clarified if this observation originated from an artifact resulted from the methodology applied.
However, data on Foraminifera have mainly originated from geological studies that employ varied methodologies (e.g., different sieve fractions, depth intervals, wet vs. dry sorting, dead vs. live assemblages), which often hamper a thorough statistical synthesis of the data.
The rationale of our strategy, its limits and transferability Our results originated from the integrated application of three state-of-the-art methodologies, namely HPF electron microscopy, semi-automated HCA of digital TEM images and in silico cell modelling.
In our investigations towards regioselective and orthogonal cross-coupling methodologies on pyridine systems, 17 an interesting and unexpected byproduct was observed, which clearly originated from a direct arylation after C H activation (Scheme 1).
The workflow data processing methodology used in the project was based on the InforSense KDE workflow system.[22] The software originated from the Grid Computing and Service Computing developed within the Discovery Net, UK e-Science Pilot Project[23].
