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Historical comparisons between clinical trial are hazardous because there is considerable variability between study population, schedule and methodology of response evaluation, although with these considerations in mind the median survival for GEM alone, on GOIRC trial, was better than the principal studies with GEM alone (7 vs 5.7 months).
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The numerical methods for the performance analysis and the noise prediction of the centrifugal compressor impeller are developed, which are coupled with the optimization design methodology consisting of response surface method, statistical approach, and genetic algorithm.
In this paper, the modeling methodology of rapid response production systems (RRPS) is proposed, and a case study in an aircraft manufacturing company has been developed to illustrate the application of the methodology.
With this aim in mind, here we present a systematic theoretical study, based upon a large-scale configuration-interaction (CI) methodology, of linear optical response of borozene.
To describe the methodology of evaluating the response of cancer patients to interventions directed at lowering severity of multiple symptoms, and to compare two arms of a symptom management trial to determine factors associated with response and time to response.
Cephalexin synthesis was optimized using an experimental design based on surface of response methodology.
This study argues for a wider application of this methodology, including appropriate appreciation of response category functioning, whenever rating scale data are used for measurement.
Block et al.'s (1992) methodology of analysing original responses by looking at those considered statistically infrequent may be an appropriate alternative.
The central composite design and surface response methodology of different SLACs characteristics showed that the optimal responses were achieved at the same operating conditions.
The modeling abilities of the response surface methodology model and neural network model, as well as the optimizing abilities of response surface methodology and the genetic algorithm based on a neural network model were compared.
To illustrate the proposed methodology, the response of a four-story building under a seismic excitation is considered.
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