Existing approaches, such as enterprise architecture, model driven architecture, domain specific methodology, meta-modeling, framework-based development, etc., are reviewed, revealing that none offers a complete solution that supports all the aspects of the VE modeling in an elegant manner.
Trial sequential analysis is an approach that combines conventional meta-analysis methodology with meta-analytic sample size considerations as well as previously established methods for repeated significance testing on accruing data in randomized trials [ 51].
Lakatos's meta-methodology is interesting precisely because it matches his methodology: a meta-methodological research programme in the philosophy of science is progressive as long as it continues to make novel predictions.
The methodology of meta-analysis is presented in Table 2. Meta-analyses, typically applied to the results of randomized clinical trials, also increasingly address the findings of observational clinical studies [ 18].
I have written at length about the methodology of meta-analysis as applied to econometric studies [15, 16], and have used meta-analysis for a number of different data sets, including several meta-regression analyses of alcohol effects (e.g., [7, 17, 18]).
In order to understand historicism, one must also understand the distinction between methodology and meta-methodology.
To assess the methodology of meta-analyses published in leading general and specialist medical journals over a 10-year period.
Methods: We performed a systematic review according to the Cochrane Collaboration methodology, including meta-analysis, risk of bias assessment and trial sequential analysis (TSA).
We believe that, as a newly emerging methodology, the meta-analysis approach has the potential to become an integral part of our toolbox that will expedite the search for complex human disease genes.
Despite these promising outcomes, little consensus exists as to whether 1 treatment is more efficacious than others, in part because cross-study differences in methodology render meta-analyses difficult, and in part because many studies fail to document duration of treatment effects or generalization to daily activities.
Cochrane systematic review methodology with meta-analysis and trial sequential analysis of randomized trials comparing the effect of psychodynamic therapies versus 'treatment as usual' for major depressive disorder.
