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Whereas the G-BA mainly follows the methodology laid down by the IQWiG, which requests RCT data wherever feasible [20], the EMA also uses sources such as non-clinical studies or even expert advice to put data from pivotal trials into context.
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The methodology is laid down in two ISO standards: ISO 14040 and 14044.
That laid down a marker.
The scorekeeper laid down his pencil.
Rivers has already laid down the law.
The fifth day he laid down varnish.
The Colts never laid down on Tony Dungy.
He laid down the ground rules.
Mr. Boehner has laid down his markers.
They laid down a few simple guidelines.
I laid down my pencil.
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